WebVascular Biology and Metabolism. The cardiovascular system consists of the heart, blood, and blood vessels (arteries and veins) and serves essential roles in nutrient transport, tissue regeneration, wound healing, the immune response, and development. The narrowing of arteries (called atherosclerosis) is the primary cause of heart attacks ...
Deficient eNOS Phosphorylation is a mechanism for diabetic …
WebNina D. Anfinogenova, Mark T. Quinn, Igor A. Schepetkin, Dmitriy Atochin . Publication. Cells. Abstract. Neuroinflammation is involved in the progression or secondary injury of multiple brain conditions, including stroke and neurodegenerative diseases. Alarmins, also known as damage-associated molecular patterns, are released in the presence of ... WebSep 1, 2011 · Dmitriy N Atochin; Nitric oxide (NO) is a well-known gaseous mediator that maintains vascular homeostasis. Extensive evidence supports that a hallmark of endothelial dysfunction, which leads to ... bismuthfluorid
Alarmins and c-Jun N-Terminal Kinase (JNK) Signaling in ...
WebAug 8, 2024 · A novel specific inhibitor of c-Jun N-terminal kinase, 11 H -indeno[1,2- b ]quinoxalin-11-one oxime sodium salt (IQ-1S), has a high affinity to JNK3 compared to JNK1/JNK2. The aim of this work was to study the mechanisms of neuroprotective activity of IQ-1S in the models of reversible foca … WebDmitriy Atochin. Massachusetts General Hospital. Verified email at cvrc.mgh.harvard.edu. Akt-NO-cGMP-SMC signaling CBF stroke CVD. Articles Cited by Public access Co … WebA novel dual NO-donating oxime and c-Jun N-terminal kinase inhibitor protects against cerebral ischemia-reperfusion injury in mice. by Dmitriy Atochin. The c-Jun N-terminal kinase (JNK) has been shown to be an important regulator of neuronal cell death. Previously, we synthesized the sodium salt of 11H-indeno [1,2-b]quinoxalin-11-one (IQ … darling\u0027s auto mall ellsworth maine complaint