Cisplatin and sodium thiosulfate

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August undefined, 2024

WebJul 3, 2024 · Cisplatin is widely used for the treatment of a number of solid malignant tumors. However, ototoxicity induced by cisplatin is an obstacle to effective treatment of tumors. The basis for this toxicity has not been fully elucidated. WebDec 30, 2024 · I. Evaluate disease recurrence patterns: locoregional versus distant. OUTLINE: Patients undergo cytoreduction. Patients also undergo HIPEC over 60 minutes consisting of doxorubicin and cisplatin. Patients then receive sodium thiosulfate intravenously (IV) over 12 hours.

Sodium Thiosulfate for Protection from Cisplatin-Induced Hearing …

WebThe major toxicities of a cisplatin overdose include nausea and vomiting, renal insufficiency, electrolyte abnormalities, myelosuppression, ototoxicity, peripheral … WebSep 22, 2024 · On September 20, 2024, the U.S. Food and Drug Administration (FDA) approved the use of sodium thiosulfate (Pedmark®) to reduce the risk of ototoxicity associated with cisplatin in pediatric patients aged 1 month and older with localized, nonmetastatic solid tumors. greeting cards for golfers

Hear Me Out: Mitigating Cisplatin-Induced Ototoxicity

WebFeb 14, 2024 · Sodium thiosulfate injection was approved by the FDA in September 2024 to help decrease the risk of hearing loss in patients 1 month or older with localized, non-metastatic solid tumors who will receive treatment with cisplatin. 2 The injection was evaluated in 2 clinical trials: the phase 3 SIOPEL6 trial (NCT00652132) in a pediatric … WebSep 21, 2024 · About PEDMARK® (sodium thiosulfate injection) PEDMARK ® is the first and only U.S. Food and Drug Administration (FDA) approved therapy indicated to reduce … WebJun 21, 2024 · Sodium Thiosulfate for Protection from Cisplatin-Induced Hearing Loss P.R. Brock and Others greeting cards for inmates

Efficacy of Sodium Thiosulfate and Mannitol in Reducing …

Sodium Thiosulfate for Prevention of Ototoxicity in Patients With ...

WebToxicity of cisplatin can be decreased by concomitant administration of sodium thiosulfate, which perhaps chemically inactivates this platinum compound. We studied … WebApr 9, 2024 · In the COG ACCL0431, the hearing loss incidence rate was 28.6% in patients treated with sodium thiosulfate plus cisplatin compared with 56.4% in the cisplatin … greeting cards for grandmaWebSodium thiosulfate is a neutralizing agent for cisplatin that protects against renal damage. To determine whether injection of thiosulfate would permit larger doses of cisplatin to … greeting cards for great granddaughter

"WebMar 29, 2024 · An important step forward in addressing this was the recent approval of intravenous sodium thiosulfate by the US Food and Drug Administration to treat ototoxicity in pediatric patients with localized, nonmetastatic solid tumors. 11 However, for adult patients, there are no currently approved therapies for cisplatin-induced ototoxicity. Until ... " - Cisplatin and sodium thiosulfate

Cisplatin and sodium thiosulfate

High-dose cisplatin with sodium thiosulfate protection

Webcompared cisplatin with cisplatin plus delayed administration of sodium thiosulfate, aiming to reduce the incidence and severity of cisplatin-related ototoxic effects … WebThe chemotherapy agent cisplatin is essential for treatment of many paediatric and adolescent malignancies but in a large proportion of patients results in cisplatin-induced …

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WebJul 6, 2024 · Now, results of the randomized, phase III SIOPEL 6 trial demonstrate that sodium thiosulfate (STS) has considerable efficacy in preventing cisplatin-induced … WebCisplatin is a bedrock of cancer management and one of the most used chemotherapeutic agents in the treatment of germ cell, lung, bladder, ovarian, and head and neck cancers. Approximately 500,000 patients diagnosed annually with these cancer types in the United States could be candidates for treatment with cisplatin. There is a 5-fold increase in the …

WebFeb 17, 2024 · Cisplatin extravasation, concentrated: Infants, Children, and Adolescents: Inject 2 mL of a 1/6 M (~4%) sodium thiosulfate solution into existing IV line for each 100 mg of cisplatin extravasated; consider also injecting 1 mL of a 1/6 M (~4%) sodium thiosulfate solution as 0.1 mL subcutaneous injections (clockwise) into the area around … WebSodium thiosulfate interacts directly with cisplatin to produce an inactive platinum species; In addition, sodium thiosulfate can enter cells through sodium sulfate cotransporter 2 …

WebFeb 1, 2024 · This medicine is given 6 hours after receiving cancer medicine (eg, cisplatin). You may also receive other medicine (eg, allergy medicine, steroid medicine) or … WebCisplatin-induced ototoxicity is caused by irreversible damage to hair cells in the cochlea hypothesized to be due to a combination of reactive oxygen species production and direct alkylation of DNA leading to cell death. Sodium thiosulfate interacts directly with cisplatin to produce an inactive platinum species. Regulatory Status

WebSep 22, 2024 · Sodium thiosulfate is administered as an IV infusion over 15 minutes following cisplatin infusions of 1–6 hours. View the full prescribing information for …

WebApr 3, 2008 · Beginning within 3 weeks after surgery, patients receive cisplatin IV over 6 hours and sodium thiosulphate IV over 15 minutes (as in neoadjuvant therapy) on day 1. Treatment repeats every 2 weeks for 2 courses in the absence of disease progression or unacceptable toxicity. greeting cards for husband from wifeWebSep 9, 2024 · Sodium thiosulfate is a type of medication used to treat cyanide poisoning and to help lessen the side effects from cisplatin. Chemotherapy drugs, such as cisplatin, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. greeting cards for international women\\u0027s dayWebApr 25, 2024 · Drug: Cisplatin Drug: Sodium thiosulfate Procedure: Cytoreductive surgery: Phase 2: Detailed Description: Adrenocortical carcinoma (ACC) is a rare tumor with an overall 5-year mortality rate of 75 - 90% and an average survival from the time of diagnosis of 14.5 months. The treatment of choice for a localized primary or recurrent … focus acrylic glossWebOct 6, 2024 · Sodium thiosulfate prevents hearing loss and is safe. Cisplatin belongs to a group of platinum-based chemotherapy drugs. Research has suggested that hearing … focus acrylic paintWebApr 7, 2024 · On 30 March 2024, the European Medicines Agency’s (EMA’s) Committee for Medicinal Products for Human Use (CHMP) adopted a positive opinion, recommending … focus active 2020WebAug 11, 2024 · About Sodium Thiosulfate (STS) Cisplatin and other platinum compounds are essential chemotherapeutic components for many pediatric malignancies. Unfortunately, platinum-based therapies cause ototoxicity in many patients, and are particularly harmful to the survivors of pediatric cancer. focus active hatchback pivdWebJun 21, 2024 · The addition of sodium thiosulfate, administered 6 hours after cisplatin chemotherapy, resulted in a lower incidence of cisplatin-induced hearing loss among … focus active 2021